http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111646889-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3970ff2929243c84b2f197df598b9c59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_509dcdee307c173971b32910685d906e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-09 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-708 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-09 |
| filingDate | 2020-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f119e29bcffaa3e85b8d0510204def99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f392324300f375bcb203c053ff1c9fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ce6260a33b4baf0634f5c108cca73a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a7def51684a715b4ab9fb59d09874b0 |
| publicationDate | 2020-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111646889-A |
| titleOfInvention | Green Synthesis Method of Pharmaceutical Active Molecules GC-24 and Furugrelic Acid |
| abstract | The present invention discloses a green synthesis method of medicinal active molecules GC-24 and furogrelic acid. From a structural point of view, both of them contain diarylmethane structures. The present invention uses cheap and easily available benzyl alcohol and aryl electrophiles as raw materials, and uses dimethyl oxalate (33 yuan/100g) as an activator. Under the catalysis of nickel, the key framework was constructed in one step using a reductive coupling strategy. Simple operation and convenient synthesis. The synthesis of GC‑24 is reduced from 10 steps to 4 steps compared with the existing best preparation method; the use of highly corrosive and irritating chemicals such as HBr and BCl 3 and the use of expensive drugs such as palladium metal catalysts and carbene ligands are avoided . The synthesis of furugrelic acid not only shortens the original preparation route by half, but also avoids the use of strong corrosive reagents such as nitric acid, sulfuric acid and trifluoroacetic acid, and avoids flammable and explosive processes such as catalytic hydrogenation and diazotization. The synthesis of the two types of drugs has good step economy and atom economy. |
| priorityDate | 2020-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 160.