http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111635450-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J63-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate | 2020-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111635450-B |
| titleOfInvention | Compound with anti-diabetic activity in plumeria rubra and preparation method thereof |
| abstract | The invention discloses four compounds with anti-diabetic activity in plumeria and a preparation method thereof, wherein the four compounds are novel compounds 1, 2 and 4 which are triterpenoids lup-20(29) -en-3 respectively β ‑(1‑(2 S -hydroxypionate) -benzoic acid) (1), iridoid compounds β ‑dihydroplumericin A(2)， β -dihydroplircinic acid (3), pyrone compound tetrahydroxy-4 S ‑hydroxy‑6 β -heptadeceyl-2H-pyran-2-one (4), and the anti-diabetic effect of compounds 1-4 of the above frangipani was further investigated by photoabsorption detection assay. The results show that compounds 1-4 are paired α The inhibition of glucoronidase is stronger than that of acarbose which is a positive control, and particularly the activity of the compound 1 is particularly outstanding; the compound 1 has stronger inhibitory action on PTP1B than that of positive control oleanolic acid, and has stronger activity. The invention discovers a compound with novel structure and anti-diabetic activity from frangipani, and lays a foundation for preparing a new anti-diabetic medicine. |
| priorityDate | 2020-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.