http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111632049-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_70fbe08b7c540157200696115221f654 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 |
filingDate | 2020-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d8d41f9241e0e967cd71c27861ed9b0 |
publicationDate | 2020-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-111632049-A |
titleOfInvention | A compound formula for relieving testicular aging damage by comprehensively correcting metabolic disorder of cellular reactive oxygen species |
abstract | The invention discloses a compound formula for relieving testicular aging damage by comprehensively correcting cell reactive oxygen species (ROS) metabolic disorder. The main components are: melatonin (0.5-3mg/d), lipoic acid (50-500mg/d) , Nicotinamide ribose (50-700mg/d). There are ingenious metabolic synergies in the formula ingredients: nicotinamide ribose promotes the production of the main carrier of reduction potential and free energy, so that lipoic acid acts as a redox switch to fully eliminate ROS damage in testicular cells; NADPH oxidase generated by nicotinamide ribose metabolism catalyzes the generation of maintenance The self-renewal second messenger ROS of testicular spermatogonial stem cells can cleverly avoid lipoic acid and melatonin to eliminate the side effects of ROS interfering with spermatogenesis. The formula uses high-throughput standard cell experiments and randomized double-blind controlled multi-center volunteer experiments to accurately identify the effects and toxicity thresholds of each component of the formula, so that the dosage of each component has a strong tolerance and safety. It is suitable as a core formulation for related product development. |
priorityDate | 2020-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 262.