| abstract |
The present invention is a recombinant adenovirus and a stem cell containing the virus, which has excellent ability to load stem cells and can also be well loaded into stem cells at low concentrations, and is a component of gene transfer. In addition, the present invention relates to a pharmaceutical composition whose stem cell-loaded adenovirus has an in vivo viability and an excellent therapeutic effect on tumors. Stem cells into which the adenovirus of the present invention has been introduced as an anticancer agent have excellent elasticity in vivo and have a therapeutic effect on tumor cells, and when used as an anticancer agent do not cause residual or hepatotoxicity in stem cells, so they can be injected systemically, It has excellent anticancer effects even at low doses and is widely available as an adenovirus anticancer agent. |