http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111620929-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 |
| filingDate | 2020-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111620929-B |
| titleOfInvention | Synthetic peptide brap and its application in the preparation of anti-inflammatory drugs for new coronary pneumonia |
| abstract | The invention discloses a synthetic peptide brap and its application in preparing an anti-inflammatory drug for new coronary pneumonia, and belongs to the technical field of biomedicine. A synthetic peptide brap whose amino acid sequence is shown in SEQ ID No.1. brap has obvious target docking and inhibitory effects on G protein-coupled bradykinin B1 and B2 receptors; nasal administration of brap has local effects on allergic nasal inflammation and on lung leakage, lung injury and LPS Systemic pharmacodynamic effects of induced cytokine storm. Intravenous injection of brap can significantly inhibit the excessive inflammation and oxidative stress and severe lung injury in LPS-induced mice, and inhibit the excessive release of pro-inflammatory factors IL-6 and TNF-α in LPS-induced inflammatory factor storm The overexpression of mRNA and IL-6 mRNA and the large production of reactive oxygen species (RSO) were significantly inhibited. |
| priorityDate | 2020-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 358.