http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111620830-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6e7a2196a2c6da77ca8f1afb4f1d8c7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2015-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_397e80cc6127f17b75ca239778a6d071 |
| publicationDate | 2020-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111620830-A |
| titleOfInvention | Small molecule used to inhibit male fertility |
| abstract | Compounds suitable for use in providing male contraception, assays to identify these compounds, and methods of using the compounds to provide contraception are provided. In one embodiment, the compounds described herein mimic the binding of anti-EPPIN antibodies to EPPIN, thereby inhibiting the forward motility of human and other primate sperm. In another embodiment, the compounds described herein inhibit or enhance the binding of EPPIN-Semen coagulation protein and inhibit the forward motility of sperm. The assays described herein can identify compounds that inhibit sperm motility and can be performed in a high-throughput fashion using labeled recombinant EPPIN and semen coagulation proteins. The compounds can be used in oral or transdermal compositions to temporarily and reversibly inhibit male fertility. It can also be used in addition to or instead of spermicides in spermicidal compositions, for example in conjunction with condoms, diaphragms and spermicidal jellies. |
| priorityDate | 2014-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 487.