http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111617246-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y40-00 |
| filingDate | 2020-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2023-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2023-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111617246-B |
| titleOfInvention | A kind of self-assembled nanoparticles of pure photosensitizer and its preparation and application |
| abstract | The invention belongs to the technical field of medicine, and relates to a self-assembled nanoparticle of a pure photosensitizer, so as to achieve high drug loading, good stability, low toxicity and side effects, specific disintegration of tumor sites, and slow down aggregation-induced fluorescence quenching (ACQ) effect. effect and enhance antitumor activity. The invention provides a self-assembled nanoparticle of a pure photosensitizer. The nanoparticle is self-assembled by a photosensitizer alone, or self-assembled by a photosensitizer and a PEG modifier through core-shell matching. The photosensitizer is one or more of pyropheophorbide a, chlorophyll a, pheophorbide a, pyropheophorbide a hexyl ether, and chlorin e6. The PEG modifier is an amphiphilic PEG modifier, an amphiphilic polymer of PEG and a photosensitizer. The weight ratio of the photosensitizer to the PEG modifier is: 10:0.5-10:3. The present invention provides a new strategy and more options for the development of pure drug self-assembly delivery system, and meets the urgent demand for high-efficiency chemotherapy preparations in clinic. |
| priorityDate | 2020-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.