| abstract |
The invention discloses a PARP1 protein degradation agent and its application in anti-tumor. The degradation agent includes structural formula as A compound; wherein, L is a hydrophobic linking unit; B is an E3 ubiquitin ligase ligand. The PARP1 protein degradation agent prepared by the invention can effectively degrade PARP1 protein, inhibit cell proliferation, and induce tumor cell apoptosis. At the same time, when used in combination with chemotherapy drugs, it has the effect of enhancing the efficacy of chemotherapy, and has almost no physiological toxicity. This compound is expected to provide an ideal way to improve the treatment of various diseases caused by excessive activation of PARP1. |