| abstract |
The invention discloses a preparation method of the fos-latenofovir impurity shown in formula II, and the reaction scheme of the preparation method is as follows: The reaction is carried out under the catalysis of a composite catalyst; the composite catalyst is composed of an organic base A and an organic base B, and the organic base A is selected from triethylamine, N,N-diisopropylethylamine, diisopropylethylamine, At least one of ethylamine and diisopropylamine, and the organic base B is selected from at least one of 4-dimethylaminopyridine, imidazole, pyridine, and 4-lutidine. The invention has the advantages of high reaction conversion rate and high purity of the obtained product. |