http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111606923-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2020-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111606923-B |
| titleOfInvention | Synthesis method of racemic clopidogrel |
| abstract | The invention relates to a synthesis method of racemic clopidogrel, which comprises the following steps: 1) uniformly mixing methyl benzoylformate, N-chlorosuccinimide, palladium acetate, a ligand and trifluoroacetic acid, and performing ortho-position chlorination to obtain o-chlorobenzoyl methyl formate; 2) uniformly mixing methyl o-chlorobenzoyl formate and 2-thiophene ethylamine, adding sodium cyanoborohydride and a small amount of acetic acid, and carrying out reductive amination reaction to obtain 2- (2-thiophene ethylamine) (2-chlorphenyl) methyl acetate; 3) uniformly mixing 2- (2-thiophene ethylamino) (2-chlorphenyl) methyl acetate, paraformaldehyde and an acid solution, and carrying out cyclization reaction to obtain racemic clopidogrel. The synthesis method has the advantages of low cost, mild and easily-controlled reaction conditions, and about 50% of overall yield, and has good industrial production prospect. |
| priorityDate | 2020-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.