http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111606827-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-24 |
| filingDate | 2020-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111606827-B |
| titleOfInvention | A kind of method for preparing edoxaban chiral amine intermediate |
| abstract | The present invention provides a kind of safe and convenient more suitable for industrial production to prepare N-[(1R, 2S, 5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamic acid tert-butyl ester Methods. With compound N-[(1R, 2R, 5S)-5-[(dimethylamino) carbonyl]-2-hydroxycyclohexyl] tert-butyl carbamate as raw material, use hydrocarbons such as toluene, n-heptane as reaction Solvent, in the presence of DBU, reacts with diphenylphosphoryl azide to obtain N-[(1R, 2R, 5S)-5-[(dimethylamino)carbonyl]-2-[(diphenoxyphosphoryl)oxyl ] cyclohexyl] tert-butyl carbamate and DBU azide mixture, then add a suitable base, replace the phosphate with the azide generated in the system to obtain the corresponding azide N-[(1R, 2S, 5S) -2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]carbamic acid tert-butyl ester; then by reducing the azide group to obtain the corresponding amino product N-[(1R, 2S, 5S)-2-amino -5-[(Dimethylamino)carbonyl]cyclohexyl]tert-butyl carbamate. |
| priorityDate | 2020-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.