http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111588706-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 |
| filingDate | 2020-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111588706-B |
| titleOfInvention | Mercaptopurine nanoparticles and preparation method thereof |
| abstract | The invention discloses mercaptopurine nanoparticles and a preparation method thereof. Including: (1) dissolving PLGA in an organic solvent to form a PLGA oil phase O; (2) dissolving the solid mercaptopurine in an inner aqueous phase containing a stabilizer to form an aqueous mercaptopurine solution W1; (3) adding it to the PLGA oil Form W1/O colostrum emulsion in phase O; (4) inject W1/O colostrum emulsion into outer water phase W2 to obtain W1/O/W2 double emulsion emulsion; (5) remove organic solvent and solidify to form nanoparticles; (6) After washing and dispersing, add a freeze-drying protective agent to freeze-dry, and obtain. The invention uses PLGA as a carrier to prepare mercaptopurine nanoparticles, can control the release of drugs according to the molecular weight of PLGA and the ratio of polymers, can effectively improve the bioavailability of drugs with poor water solubility, the preparation method is simple, and the prepared nanoparticles have uniform particle size, The encapsulation efficiency is good, the drug loading capacity is high, the oral administration is convenient, and the nanoparticles after lyophilization are convenient for children to divide the dose. |
| priorityDate | 2020-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.