http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111575306-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2020-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111575306-B |
| titleOfInvention | A method for activating gamma globin gene expression in red blood cells |
| abstract | The invention discloses a method for activating the expression of gamma globin gene in erythrocytes, and discloses the application of transcription factor ERF and its related elements in improving the expression of gamma globin gene HBG in erythrocytes. By methylating the cytosine deoxyribonucleotide site in the promoter region of the transcription factor ERF gene in hematopoietic stem cells, knocking out the binding site of the upstream ERF of HBG2 or knocking out the binding site of the downstream ERF of HBG1, it is possible to improve the effect of The expression of HBG in the red blood cells differentiated from the stem cells increases the content of HbF, thereby reducing the ratio of α-to-non-α-globin chains or improving the imbalanced state of the ratio of α- and non-α-globin chains. These new targets and their editing are of great significance for the diagnosis of β-thalassemia and the study of in-depth molecular mechanisms. |
| priorityDate | 2020-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 381.