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filingDate 2020-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111574576-B
titleOfInvention Refining method of diquafosol sodium
abstract The invention discloses a refining method of diquafosol sodium, which comprises the following steps: and (3) adjusting the pH value of the crude product solution of the diquafosol sodium by hydrochloric acid, adding calcium salt, stirring and dissolving, slowly dropwise adding sodium hydroxide to adjust the pH value, standing for crystallization, adding an alcohol solvent, heating, filtering while hot, and cooling for crystallization to obtain a fine product of the diquafosol sodium. The diquafosol sodium obtained by the invention is used for preparing a preparation, and does not generate precipitation and turbidity after being placed for a long time.
priorityDate 2020-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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