| abstract |
The invention belongs to the technical field of medicines, and relates to phenyl-substituted thieno [2,3-d ] pyrimidine-2, 4(1H,3H) -diketone compounds, application thereof and a pharmaceutical composition containing the compounds, which can be used as gonadotropin releasing hormone receptor antagonists. The invention also relates to methods for preparing such compounds and pharmaceutical compositions, and their use in the prevention or treatment of sex hormone dependent diseases, including but not limited to prostate cancer, endometriosis, uterine fibroids, precocious puberty, and the like. |