| abstract |
The invention belongs to the technical field of external oral cancer treatment materials, and particularly relates to an Oral Submucosal Fibrosis (OSF) hydrogel medical dressing which is one of oral precancerous lesions and is alginate/acrylic acid/montmorillonite composite hydrogel of chemical cross-linked cesium ions. In addition, the invention also provides a preparation method and application of the hydrogel. According to the composite hydrogel disclosed by the invention, cesium ions are innovatively added into the alginate/acrylic acid/montmorillonite composite hydrogel, the cell protection effect of the hydrogel on the damaged arecoline is regulated, the inflammatory reaction of oral epithelial cells can be reduced, the secretion of oral mucosa adhesive protein is increased, so that an epithelial barrier is constructed, the collagen disorder state is regulated, the further damage of the arecoline is prevented, and the OSF is prevented from being deteriorated into oral cancer, so that the purpose of preventing is achieved. |