http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111560005-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 |
| filingDate | 2020-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111560005-B |
| titleOfInvention | Preparation method of 2-thiopheneacetyl chloride |
| abstract | The invention discloses a preparation method of 2-thiophene acetyl chloride, belonging to the technical field of chemical synthesis. The preparation method comprises the following steps: (1) dissolving 2-thiophene ethanol in an organic solvent, and reacting at 50-120 ℃ under the action of a solid acid catalyst, alkali and an oxidant to prepare 2-thiophene acetic acid; the oxidant is oxygen or hydrogen peroxide; (2) dissolving 2-thiopheneacetic acid in an organic solvent, taking an alkaline ionic liquid as a catalyst, and dropwise adding thionyl chloride to carry out acyl chlorination reaction to prepare 2-thiopheneacetyl chloride. The preparation process has the advantages of simple route, easily obtained raw materials, mild reaction conditions, less by-products and easy purification and separation, and oxygen or hydrogen peroxide is used as an oxidant in the synthesis of 2-thiopheneacetic acid; in the acyl chlorination reaction of 2-thiopheneacetic acid, the alkaline ionic liquid is used as the catalyst, the reaction process is stable and easy to control, the product yield is high, the byproducts are few, and the method is an efficient green synthesis process. |
| priorityDate | 2020-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 114.