http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111544602-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a8ba8f44212daf3089a41cca1f8d79f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 |
| filingDate | 2020-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72a7176a986f9d72974af14af141937f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26469ff2175b700c521b9f4d3b4380b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4af65009062ec991d34a0bc4d0ee040a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_099322dcda239e20fca47084649fbc59 |
| publicationDate | 2020-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111544602-A |
| titleOfInvention | Application of a quaternized natural polymer material as a viral carrier delivery enhancement material |
| abstract | The invention discloses the application of a quaternized natural polymer material as a viral vector delivery enhancing material. The quaternized natural polymer material can be used for viral vector delivery. The preparation steps are: 1) preparing a Aqueous solution of amine-based natural macromolecules; 2) adding epoxy alkyl short alkyl chain quaternary ammonium salt or chlorohydroxypropyl short alkyl quaternary ammonium salt whose short alkyl carbon number is X to react, and the X=1 ~6; 3) Precipitation, washing and drying to obtain a quaternized natural polymer delivery material. The viral vector delivery enhancing material of the present invention can reduce the toxicity of high dose (titer) viral vector to cells, improve nucleic acid delivery efficiency and biocompatibility, and at the same time reduce the effect of neutralizing antibody on viral vector infection efficiency under pre-existing immune conditions. Inhibition, improve the nucleic acid delivery efficiency of viral vectors. |
| priorityDate | 2020-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.