http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111544598-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6949 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-644 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 |
| filingDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111544598-B |
| titleOfInvention | Ferritin nanoparticles loaded with Survivin dual inhibitors and its preparation method and application |
| abstract | The invention discloses ferritin nanoparticles loaded with Survivin dual inhibitors, its preparation method and application, and the application of Survivin dual inhibitors in combination in the preparation of drugs for treating tumors. The dual inhibitors include small molecule inhibitors YM155 and protein inhibitors Agent TmSm. The nanoparticle obtained by the present invention has a nanocage spherical structure, no adhesion, small particle size, narrow range, convenient for intravenous injection, and good targeting effect; the nanoparticle can be effectively cut by MMP-2 secreted by cancer cells to release TmSm protein, And actively target cancer cells through TfR1 on the surface of cancer cells, and release YM155 in the nucleus. Ferritin nanoparticles loaded with dual inhibitors of Survivin can achieve synergistic inhibition of Survivin transcription and protein levels and achieve strong anti-tumor efficacy. |
| priorityDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.