http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111533789-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 |
| filingDate | 2020-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111533789-B |
| titleOfInvention | Tryptophan and lysine chain-crossing interaction beta-hairpin antibacterial peptide and preparation method thereof |
| abstract | The invention provides beta-hairpin antibacterial peptide with tryptophan and lysine cross-chain interaction and a preparation method thereof. The sequence of the antibacterial peptide WKFPG is shown in SEQ ID No. 1. The preparation method takes the distribution principle of beta-hairpin side chains and the interaction of tryptophan and lysine as the force for assisting the PG corner unit to form the hairpin structure, so as to form the antibacterial peptide with the beta-hairpin structure and stable chemical structure and biological function. The antibacterial peptide is applied to the preparation of medicaments for treating infectious diseases caused by gram-positive bacteria or/and gram-negative bacteria. The antibacterial peptide has a sequence length of 12, contains 5 positive charges and 50% of hydrophobic amino acids, has very low hemolytic activity and salt particle, serum and acid-base stability on the basis of high-efficiency bacteriostasis, has a therapeutic index of 135.20, and has development potential as a green high-efficiency antibiotic substitute. |
| priorityDate | 2020-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.