http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111533676-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 |
| filingDate | 2020-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111533676-B |
| titleOfInvention | Deuterated synthesis method of indole compound |
| abstract | The invention provides a deuterated synthesis method of indole compounds, which comprises the step of carrying out deuterium exchange on the indole compounds through a carbon-hydrogen bond activation reaction guided by a guide group DG under the conditions of proper reaction temperature and time through a mixed reaction of heavy water, a catalyst, alkali and a solvent to generate deuterated indole products. The method provided by the invention has the advantages of mild reaction conditions, simple process, low cost, good selectivity of deuterated positions, high yield and deuterated rate; in addition, by adopting relatively cheap heavy water as a deuterium source, the use of an expensive deuterium source in the preparation process of the deuterated compound is effectively avoided, and the preparation cost of the deuterated compound can be further reduced. |
| priorityDate | 2020-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.