http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111521598-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94001306c54a145505ed0a920d915745 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B81C1-00349 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B81C1-00 |
| filingDate | 2020-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fe62677e0e118366c3002c459d7cafb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f99523a42e47dd379e08aa6a57751f5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa43a3305b1e39afc383a2dda2a49a60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_053764023a22d9352e2c659aed1933d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46cb5f2772930dc517a0e4a307a8b6e6 |
| publicationDate | 2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111521598-A |
| titleOfInvention | A biomimetic Raman substrate based on indwelling needle and its preparation and application |
| abstract | The present invention provides a biomimetic Raman substrate based on an indwelling needle. The substrate includes an indwelling needle tube and an adhesion layer. The adhesion layer includes a polydopamine film and a monolayer of silica nanoparticles. Specific tumor marker probes are adsorbed on the surface, and excess sites on the surface of the nanoparticles are blocked with bovine serum albumin molecules. The preparation method includes 1) dopamine hydrochloride forming a polydopamine film on the surface of the indwelling needle tube; 2) adsorbing single-layer silica nanoparticles on the surface of the polydopamine film; 3) adsorbing the tumor marker probe on the surface of the silica nanoparticles, And the excess sites on the nanoparticle surface were blocked with bovine serum albumin molecules. The indwelling needle-based biomimetic Raman substrate can be applied to the detection of tumor markers in the blood of patients, with good safety and no burden on patients, and can reflect the average level of specific tumor markers in the blood for a long time. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114748727-A |
| priorityDate | 2020-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.