| abstract |
The present invention discloses aminopyrimidine compounds represented by formula (I), as well as their preparation and use. Specifically, the present invention discloses aminopyrimidine compounds represented by formula (I), or polymorphs, pharmaceutically acceptable salts, prodrugs, stereoisomers, isotopic variants, hydrates or solvates thereof. substances, as well as pharmaceutical compositions containing them and uses thereof. The aminopyrimidine compounds disclosed in the present invention and the compositions comprising the compounds have excellent inhibitory properties on protein kinases, and at the same time have better properties of pharmacokinetic parameters, and can increase the drug concentration of the compounds in animals, so as to improve the drug efficacy and security. |