http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111518065-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0dfb750c93c0e048b5a8d74a29fe1ffd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-93 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2020-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88729bc392087d546449f98f28b7f074 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c09b47e8d80758f943130c4d92e80df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a961a6c9fbf6598c85c89f3c14fbf531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ef9d384395bd9c99dd3426e19837c38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53e1ec67ccc9f9fd7dcf81d537fd8b3a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73673f2b3c4abb4f6de66d7c34e5df2a |
| publicationDate | 2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111518065-A |
| titleOfInvention | Parthenolide derivative and preparation method and application thereof |
| abstract | The invention relates to the technical field of organic synthesis, in particular to a parthenolide derivative and a preparation method and application thereof. In the present invention, parthenium is used as the initial main raw material, and 11 parthenolide derivatives are synthesized through a series of chemical reactions, and these derivatives have certain anti-proliferative activity on glioblastoma cells. The present invention also confirms that the deuterium-containing derivative DMAPT-D6 can significantly induce the accumulation of reactive oxygen species in glioblastoma cells, thereby causing DNA damage in glioblastoma cells. Furthermore, DMAPT‑D6 promotes exogenous apoptosis mediated by caspase-dependent death receptors, suggesting that DNA damage induced by DMAPT‑D6 induces apoptosis in glioblastoma cells. Taken together, ROS accumulation induced by DMAPT‑D6 treatment leads to DNA damage followed by death receptor-mediated apoptosis, suggesting that DMAPT‑D6 with novel components has therapeutic potential for the treatment of glioblastoma, which may The invention is used in the preparation of drugs for treating glioblastoma. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115403545-A |
| priorityDate | 2020-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 161.