| abstract |
The invention discloses a preparation method of an anti-tumor polymer bonded drug with multi-drug synergy, which is characterized by comprising the following steps: Step S1, single-end epoxy polyether modified amino-terminated hyperbranched polylysine acid; step S2, ionization modification; step S3, bonding of anticancer drugs. The invention also discloses the anti-tumor polymer bonded drug with multi-drug synergistic effect prepared according to the preparation method of the anti-tumor polymer bonded drug with multi-drug synergistic effect. The anti-tumor macromolecule bonded drug with multi-drug synergistic effect disclosed in the invention combines the anti-cancer mechanisms of various anti-cancer drugs, and the synergistic effect enables the anti-cancer activity to be high, the toxic and side effects are small, and the biocompatibility is good. , high drug loading, biodegradable. |