http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111499572-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 |
| filingDate | 2019-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111499572-B |
| titleOfInvention | Preparation method of intermediate of roxasistat |
| abstract | The invention discloses a preparation method of a rosinestat intermediate, which relates to the technical field of medicine preparation, and is characterized in that 3-oxo-3- (4-phenoxyphenyl) propionate is taken as a raw material to prepare 2-acetamido-3-oxo-3- (4-phenoxyphenyl) propionate, and then 4-hydroxy-1-methyl-7-phenoxyl-3-isoquinoline formate is obtained through cyclization reaction. The method has the advantages of novel line, short synthesis line, easy acquisition or preparation of all raw material reagents, no use of reagents with high risk and high pollution, safety, environmental protection, mild reaction conditions, convenient and controllable operation, good purity and high yield of the prepared intermediate of the roxasistat, obvious cost advantage and suitability for industrial production. |
| priorityDate | 2019-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.