| abstract |
The invention discloses a nucleic acid medicine for treating chronic pain, and belongs to the field of analgesic medicines. The active component of the nucleic acid medicament is siRNA or shRNA for inhibiting NALCN expression, and the siRNA or shRNA is combined with a specific liposome, a cationic polymer micelle or an adeno-associated virus vector, so that the nucleic acid medicament can effectively treat neuropathic pain and inflammatory pain, and has long duration of medicament effect. The medicine of the invention is expected to replace the existing analgesic medicine and has good application prospect. |