| abstract |
The present invention relates to the role of miRNA-483-3p in regulating blood pressure, heart and blood vessels in spontaneously hypertensive rats. It can keep the systolic blood pressure, diastolic blood pressure and mean arterial pressure in the initial range without increasing continuously in spontaneously hypertensive rats; it can significantly increase cardiac ejection fraction and left ventricular short-axis shortening rate , the cardiac weight index decreases, thereby significantly improving the structure and function of the heart; it can reduce the collagen fibers of the abdominal aorta, the intima is significantly thinned, the lumen is widened, and the endothelial cells are arranged neatly, thereby making the abdominal aorta structure, thickness, internal Membrane integrity was improved to varying degrees. Therefore, the miRNA-483-3p disclosed in the present invention can be used as a new target for hypertension treatment. |