http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111494388-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 |
| filingDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111494388-B |
| titleOfInvention | Application of YM201636 and its pharmaceutically acceptable salt in preparation of medicine for resisting enterovirus infection |
| abstract | The invention belongs to the technical field of biotechnology and biological medicine, and discloses application of YM201636 and pharmaceutically acceptable salts thereof in preparation of an anti-enterovirus infection medicine. The molecular formula of YM20163 is: c 25 H 21 N 7 O 3 (ii) a The structural formula is as follows. Based on the commonality of replication of enteroviruses in host cells, the invention adopts a small molecular compound YM201636 to specifically target host cell PIKFYVE protein, so that the component of an organelle membrane is blocked, namely, the link from early endosome to late endosome is inhibited, the normal formation of an endosome sorting and transporting complex (ESCR) membrane transporting complex is blocked, and an ESCR complex-mediated enterovirus replication complex is destroyed, thereby inhibiting the replication level of the enteroviruses, achieving the aim of controlling various enteroviruses and realizing the broad-spectrum and high-efficiency anti-enterovirus effect. |
| priorityDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.