| abstract |
The invention provides a biological nano-robot for treating aortic dissection, which belongs to the field of medical devices. The invention provides a biological nano-robot for treating aortic dissection, comprising: prothrombin; a magnetic biological shell for wrapping the prothrombin; aortic smooth muscle cell surface antigen-specific antibody, arranged outside the magnetic biological shell On the surface, it is used to bind to the surface antigen of aortic smooth muscle cells; coagulation factor Xa, chimeric on the outer surface of the magnetic bioshell, is used to bind to prothrombin, generate thrombin, and initiate the coagulation reaction; and switch proteins, It is arranged on the surface of the magnetic biological shell, and is used to open the biological shell and release the prothrombin after the antigen-specific antibody on the surface of the aortic smooth muscle cell is combined with the surface antigen of the aortic smooth muscle cell. The invention can achieve non-invasive cure of aortic dissection, not only avoids the risk of surgical operation, reduces medical cost, but also innovates the medical method. |