abstract |
The application relates to compounds of formula (I), wherein R1, R2, R3, R4, X, Y and A are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and are useful in the treatment of Duchenne muscular dystrophy. Accordingly, the present invention further relates to pharmaceutical compositions comprising the compounds of the present invention. The present invention further relates to methods of inhibiting H-PGDS activity and treating diseases associated therewith using the compounds of the present invention or pharmaceutical compositions comprising the compounds of the present invention. |