http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111471041-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 |
| filingDate | 2019-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111471041-B |
| titleOfInvention | A kind of synthetic method of oxazolidinone antibacterial drug intermediate |
| abstract | The invention discloses a method for synthesizing an oxazolidinone antibacterial drug intermediate, comprising the following steps: (1) the effect of acetate derivatives IV-1 and 2,5-disubstituted pyridine IV-2 on metal reagents Reaction occurs in an organic solvent to obtain compound IV-3; (2) compound IV-3 undergoes a reduction reaction in an organic solvent in the presence of a reducing agent to obtain compound IV-4; (3) compound IV-4 and methylamine The solution is reacted to obtain compound IV-5; (4) compound IV-5 is subjected to a salt-forming reaction with a chiral acid at 20-100 ° C, the obtained salt is recrystallized, and then dissociated under the action of a base to obtain compound III -4; (5) Compound III-4 is subjected to a cyclization reaction in the presence of a cyclization reagent to obtain the oxazolidinone antibacterial drug intermediate II-8. The method overcomes the shortcomings of using explosive azide compounds and expensive metal catalysts in the prior art, and has mild and safe reaction conditions, easy purchase of reagents, low cost, shortened reaction steps, avoids column chromatography, and is beneficial to industrial production. |
| priorityDate | 2019-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 132.