http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111471020-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 |
| filingDate | 2020-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111471020-B |
| titleOfInvention | Preparation method of apltinib intermediate |
| abstract | The invention discloses a preparation method of an apreminib (Avapritinib) intermediate (S) -1- (4-fluorophenyl) -1- [2- (piperazine-1-yl) pyrimidine-5-yl ] ethylamine, which comprises the following steps: 4-fluoro acetophenone is used as an initial raw material, and a target compound (S) -1- (4-fluorophenyl) -1- [2- (piperazine-1-yl) pyrimidine-5-yl ] ethylamine is generated through an imidization reaction, an addition reaction under the catalysis of organic metal and a hydrolysis reaction in sequence. The preparation method is simple in process, mild in condition, safe and environment-friendly, and provides a new way for industrial production of the aplinib. |
| priorityDate | 2020-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.