http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111467323-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 |
| filingDate | 2020-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111467323-B |
| titleOfInvention | Synthesis method and application of VB12 combined nano-composite carrying miRNA |
| abstract | The invention discloses a synthetic method and application of VB12 combined type nano-composite carrying miRNA. The synthetic method comprises the steps of mixing and dissolving the PLGA-PEG nano compound, the vitamin B12, the EDC and the DMAP in an anhydrous solvent A, and stirring and reacting at 15-40 ℃; after the reaction is finished, dialyzing and removing the solvent to obtain the vitamin B12 combined nano compound. The synthesis method has mild preparation conditions, cheap required raw materials, convenient operation, simple process, high efficiency and practicability. The prepared nano-composite optimizes the nucleic acid medicament in three aspects of water solubility, stability and tumor targeting, endows the nucleic acid medicament with high-efficiency and low-toxicity anti-tumor effect, and has wide application prospect in the field of tumor treatment. |
| priorityDate | 2020-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.