http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111467322-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate | 2020-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111467322-B |
| titleOfInvention | Synthesis method and application of VB12 targeted sildenafil nano-drug |
| abstract | The invention discloses a synthesis method and application of VB12 targeted sildenafil nano-drug, wherein the synthesis method comprises the steps of mixing sericin and VB12 in an anhydrous solvent A, adding CDI and DMAP for catalysis, and reacting to prepare VB12 targeted sericin; mixing and dissolving the obtained VB12 targeted sericin and alpha-amino acid-N-carboxyanhydride in an anhydrous solvent B, and fully reacting; and adding sildenafil, fully reacting, and filling the mixed solution into a dialysis bag to obtain the VB12 targeted sildenafil nano-drug. The method has the advantages of cheap raw materials, convenient operation, simple process, high efficiency and practicability, and can couple VB12 to the nano-drug carrier under mild conditions. The obtained VB12 targeted sildenafil nano-drug has stable property, high biological histocompatibility, good dispersibility in aqueous solution, tumor targeting property, rapid uptake by tumor cells, and more efficient and safe immunotherapy sensitization effect. |
| priorityDate | 2020-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.