http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111454901-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-1384 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2513-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-105 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N11-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N11-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N11-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N11-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0775 |
| filingDate | 2020-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111454901-B |
| titleOfInvention | A method for inducing differentiation of adipose stem cells into chondrocytes |
| abstract | The present invention provides a method for inducing adipose stem cells to differentiate into chondrocytes. The method includes preparing adipose stem cells-sodium alginate suspension, preparing adipose stem cells-calcium alginate microbeads, and inducing culture. The method for inducing the differentiation of adipose stem cells into chondrocytes according to the present invention utilizes an incomplete chondrogenic induction medium containing PRP and members of the transforming growth factor-beta superfamily (TGF-beta1, IGF-1, BMP-6), and the combined use PRP, a member of the transforming growth factor-β superfamily, has a synergistic effect, can up-regulate the expression of Sox-9 gene, inhibit the differentiation of adipose stem cells to a hypertrophic phenotype after induction, promote cell proliferation and improve the efficiency of induction and differentiation. The proliferative activity of chondrocytes obtained by using the method of the present invention to induce differentiation for 13-15 days is 3.4 times that of the control group A, 2.2 times that of the experimental group B, and 1.95 times that of the experimental group C. |
| priorityDate | 2020-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 185.