http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111454264-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2020-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111454264-B |
| titleOfInvention | Luotonin A series compound and preparation method and application thereof |
| abstract | The invention relates to the technical field of pharmaceutical chemistry, and discloses a Luotonin A series compound and a preparation method and application thereof. Luotonin A series compound shown as formula (I) and pharmaceutically acceptable salt thereof, wherein R is 1 Is H or halogen; r 2 Is ethylenediamine, ethylenediamine substituted by C1-C6 alkyl, piperazinyl substituted by C1-C6 alkyl, morpholinyl substituted by C1-C6 alkyl, homopiperazinyl or homopiperazinyl substituted by C1-C6 alkyl; x is C or N. The Luotonin A series compound provided by the invention has a stable structure, is easy to synthesize and prepare, can be used as a novel topoisomerase I inhibitor, and has strong antiproliferative activity on liver cancer, lung cancer, breast cancer and cervical cancer cell strains. 。 |
| priorityDate | 2020-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.