| abstract |
Disclosed are methods of treating ciliopathies-related disorders comprising administering to a subject in need thereof an effective amount of a compound targeting at least one G protein-coupled receptor. Provided are methods for identifying a therapeutic agent for the treatment of a disease with ciliopathy, comprising providing an animal model system of said ciliopathy for testing a putative therapeutic agent; administering to said animal a disruptive agent, using said putative therapeutic agent Treating the administered animal with the therapeutic agent, comparing the measurable phenotype of the treated animal to the measurable phenotype of the untreated animal, and reducing the measurable phenotype of the treated animal compared to the measurable phenotype of the untreated animal , identify therapeutic targets for the treatment of ciliopathies. |