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filingDate 2020-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111437250-B
titleOfInvention Stable mefenanamine ammonium oral solution and preparation method thereof
abstract The invention provides a stable mefenamipramine ammonium oral solution and a preparation method thereof. The mefenamipramine oral solution comprises 0.03-0.3% (w/v) of dextromethorphan hydrobromide, 0.01-0.2% (w/v) of chlorpheniramine maleate, 0.1-3.0% (w/v) of ammonium chloride, 0.02-5% (w/v) of a pH regulator, 0.01-2% (w/v) of an aromatic, 0.008-0.1% (w/v) of a coloring agent and water, and further comprises 10-25% (w/v) of propylene glycol. The mefenamipramine ammonium oral solution can take effect quickly; the formula does not contain sucrose, so incompatibility between the formula and ammonium chloride is avoided; the preservative is not contained, so that the safety of the solution is improved; the use of propylene glycol increases the solubility of dextromethorphan hydrobromide; and the content of the propylene glycol is 10-25%, so that the antibacterial effect is obvious, and no preservative is required to be added.
priorityDate 2020-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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