| abstract |
The present invention provides an antagonistic peptide, its copolymer and nano-assembly, and its preparation method and application. The antagonistic peptide is a PD-L1 antagonistic peptide, which is named M-APP and has the following structure: The invention uses M-APP as a raw material to prepare a copolymer IR780-M-APP with a clear structure, which can be self-assembled to form a nano-assembly, which not only solves the problem of poor immunogenicity in immunotherapy, but also improves the utilization rate of immune antagonistic peptides , It can also solve the problem of poor water solubility of IR780 through synergistic photodynamic therapy, improve the effect of phototherapy treatment, and enhance the efficacy of immunotherapy. |