| abstract |
The invention discloses application of a benzenesulfonamide compound as an mPGES-2 inhibitor and a medicament. Application of benzenesulfonamide compound shown as formula (I), isomer or pharmaceutically acceptable derivative thereof in preparation of mPGES-2 inhibitor, medicament for preventing and/or treating diabetes or medicament for preventing and/or treating diabetes by mPGES-2 target generation, wherein the medicament at least can inhibit islet cell PGE 2 To promote insulin secretion; the mPGES-2 inhibitor is prepared from the provided benzenesulfonamide compound, isomer or pharmaceutically acceptable derivative thereof, and experiments prove that the compound and the pharmaceutically acceptable derivative thereofThe mPGES-2 inhibitor can be used in the improvement and treatment of diabetes, and can obviously prove the effect on the improvement and treatment of diabetes, and can be prepared into a medicament for preventing and treating diabetes through an acceptable carrier. |