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filingDate 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e100a6e6a2a1922d61e1c77c1e08a1fe
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publicationDate 2020-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111410682-A
titleOfInvention Cyclization preparation method of polymyxin B related compounds
abstract The invention discloses a cyclization preparation method of polymyxin B-related compounds. The invention has simple reaction operation, convenient post-processing and high yield. The synthesis of B3 has high reference value. In addition, the present invention provides an important basis for the scientific evaluation of the efficacy, pharmacological research, pharmacokinetics, etc. of the polymyxin B through the preparation of each single constituent compound of the polymyxin B, which facilitates its metabolic process in the human body. Pharmacokinetics are further studied to make it have better medicinal prospects.
priorityDate 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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