| abstract |
The invention provides a genetically engineered bacterium for efficiently synthesizing melatonin, and a construction method and application thereof, belongs to the technical field of genetic engineering, and aims at the problems of low yield and long time consumption of the existing biosynthetic melatonin, the genetically engineered bacterium overexpresses a tryptophan synthase gene TRP5, removes indoleamine 2, 3-dioxygenase gene BNA2, and adopts Saccharomyces cerevisiae (Saccharomyces cerevisiae) as a starting strain. |