http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111393389-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_452e625b5e37cfe3a61e33239649bded |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-12 |
| filingDate | 2020-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d506aaee11ece46c51591cd6099b094f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e21cc5298834122df9b1723825426a81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14aa5b88ed56f0ad6f3be56359c1ee1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0df4931d1523a7a7c18a777b5322757 |
| publicationDate | 2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111393389-A |
| titleOfInvention | A kind of method for palladium-catalyzed synthesis of 3-(trifluoromethyl)azetidinone |
| abstract | The invention discloses a method for synthesizing 3-(trifluoromethyl)azetidinone by palladium catalysis. Add to the autoclave to carry out the reaction, then add toluene, feed carbon monoxide, add deionized water to dilute the reaction solution after the reaction is completed, extract, and spin-evaporate, and the remaining product is separated and purified with a silica gel column to obtain 3-(trifluoromethyl) nitrogen ( phenyl) heterocyclobutanone; then mix it with an organic solvent and deionized water, add ceric ammonium nitrate, stir to obtain a mixed solution; extract, dry over sodium sulfate, and separate by silica gel column chromatography to obtain 3-(trifluoro methyl)azetidinone. The preparation of 3-(trifluoromethyl) nitrogen (phenyl) tetracyclobutanone is directly realized by one-step method, and then the phenyl protecting group is removed at room temperature to obtain the target compound. The operation is simple, the reaction energy consumption is low, and the synthesis cost is low. |
| priorityDate | 2020-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.