| abstract |
The invention discloses a method for synthesizing cyclobenzaprine hydrochloride. Zinc powder 0.7-1.0g, slowly heated to 35 ℃ constant temperature reaction, the reaction time is 30-40min. In the present invention, N,N-dimethyl-3-chlorozincpropylamine is synthesized in tetrahydrofuran by N,N-dimethyl-3-chloropropylamine, iodine, 1,2-dibromoethane and zinc powder, and is further combined with 5H-dibenzo[a,d]cycloheptatriene-5-one synthesizes cyclobenzaprine, utilizes it to prepare cyclobenzaprine hydrochloride, and cooperates with a stirring reaction device, reaction control technology and washing and purifying method to improve the cyclobenzaprine hydrochloride The quality and purity of benzaprine, the synthesis reaction process is mild, the safety is high, the product yield is high and the target product purity is high, the method is simple and feasible, simple, fast, efficient and energy-saving, and is suitable for industrialized large-scale production. |