| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17adf626e56f8d99e16517b812cae562 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-1815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2404 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate |
2020-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0813b9e81319c2135af9d37d5d1b6f30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_873103df7943f63eea0f1b9b1ab582fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb492564f992a6810307fc8d561b985c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9d321027fb6849945e659303b1fb1db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4fe3c5481df40f94c239d12e52ed635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80796aa9a71a9bb5d3444112890fef4b |
| publicationDate |
2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111393243-A |
| titleOfInvention |
A kind of synthetic method of phosphochiral nucleoside medicine and medicine obtained by the method |
| abstract |
The invention discloses a method for synthesizing phosphochiral nucleoside drugs, which comprises the following steps: reacting a phosphonochloride compound and a nucleoside prodrug with a hydroxyl group under the catalysis of a chiral transition metal catalyst to obtain a phosphochiral nucleoside drug. The method adopts a specific catalyst and controls the reaction conditions, thereby improving the yield and enantioselectivity of phosphochiral nucleoside drugs, and the method is simple and feasible, suitable for scaled production, and has great promotion value. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112844472-A |
| priorityDate |
2020-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |