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filingDate 2020-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111387143-A
titleOfInvention Application of miRNA-203a-3p in the development of anti-pancreatic cancer drugs
abstract The present invention provides the application of miRNA-203a-3p in the development of drugs for inhibiting pancreatic cancer, 1) preparing a model for screening drugs for inhibiting pancreatic cancer metastasis; 2) preparing a model for inhibiting pancreatic cancer metastasis; the core of miRNA-203a-3p The nucleotide sequence is shown in SEQ ID NO:1. The present invention finds that miR-203a-3p cannot inhibit the proliferation and tumor formation of pancreatic cancer cells. However, it can induce the negatively correlated expression of the metastasis-related gene CERKL in pancreatic cancer cells, and can be used to prepare a mouse model for inhibiting pancreatic cancer metastasis. ) as a tool to develop mechanisms for metastatic tumors (pancreatic cancer).
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