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filingDate 2018-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_372b08e246df8f65dec8c6ceb6c452f4
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publicationDate 2020-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111374986-A
titleOfInvention Use of vitamin B12 as α-synuclein aggregation inhibitor in the preparation of medicines, health products or food
abstract The invention proposes the use of vitamin B12 as an α-synuclein aggregation inhibitor in the preparation of medicines, health-care products or food, and belongs to the technical field of medicine, health-care products or food. Use of vitamin B12 in the preparation of medicines, health products or foods for preventing and/or treating diseases characterized by aggregation and precipitation of α-synuclein. The application of vitamin B12 in inhibiting the aggregation of α-synuclein proposed by the present invention can effectively inhibit the aggregation of α-Syn, effectively prevent the occurrence of PD and delay the development of PD. Moreover, it effectively inhibits the toxicity of α-Syn aggregates to cells, and inhibits the aggregation of α-Syn and its conformational change process. It is an ideal drug for the treatment and prevention of Parkinson's disease.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111991412-A
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