| abstract |
The invention discloses an antibacterial hydrogel, a preparation method and application thereof, and belongs to the technical field of medical biological materials. In the present invention, the hydrogel is obtained by chemically cross-linking the hyaluronic acid with a cross-linking agent, and after freeze-drying, the hydrogel powder with relatively uniform particle size is obtained for the first time by milling and passing through sieves with different diameters. Then, the hyaluronic acid hydrogel powder was dissolved in PBS to obtain hyaluronic acid microspheres, which were mixed with the polylysine solution in proportion to obtain the obtained. The antibacterial hydrogel of the invention is convenient and quick to prepare, can effectively prevent the infection of the pacemaker implanted pocket, does not need expensive reagents, and is convenient to use. |