http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111363026-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70539 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-74 |
| filingDate | 2020-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111363026-B |
| titleOfInvention | Method for enhancing affinity and stability of antigen polypeptide |
| abstract | The invention discloses a method for enhancing the affinity and stability of antigen polypeptide, the high-efficiency presentation function of polypeptide HLA-I compound to T cell benefits from the stable interaction in the compound, compared with the affinity, the stability of HLA-I compound can reflect the immunogenicity. The invention can solve the problems of low affinity combination of a tumor specific antigen and an HLA-I molecule and poor stability of a combined polypeptide HLA-I molecule compound, is suitable for the antigen epitope modification of a tumor related antigen and a tumor neoantigen, and after single residues of amino acid residues at positions P1, P3-P9 of the HLA-I molecule restricted polypeptide epitope except position P2 are respectively replaced by His/Tyr/Trp, the affinity and the stability of the HLA-I molecule restricted polypeptide epitope are enhanced, and the specificity of the HLA-A2402 on the antigen polypeptide after residue replacement is not influenced, so the invention has higher clinical practice significance on the anti-tumor immunotherapy adopting the tumor specific polypeptide or the anti-tumor immunotherapy of T cell immunotherapy after T cell receptor modification according to the principle. |
| priorityDate | 2020-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.